Test code: 8659
CPT code(s): 85379
Clinical Significance: Venous thromboembolism (VTE) is associated with significant morbidity and mortality, and has two patterns of clinical presentation, deep venous thrombosis (DVT) and pulmonary embolism (PE). It is an important medical problem with an estimated incidence in the United States of 100,000 to 300,000 cases per year. Diagnosis relies on objective testing, as the clinical signs and symptoms of the disease are nonspecific. Various invasive and noninvasisve diagnostic procedures have been developed, but none are ideal.
D-Dimer is generated fromt he plasmin mediated lysis of cross-linked fibrin. Increased levels of D-Dimer indicate that both the procoagulant (thrombin generating pathways) and fibrinolytic systems (plasmin generating pathways) have been activated. Venous thrombosis activates both the coagulation and fibrinolytic pathways and results in elevated levels of fibrin degradation products, such as D-Dimer.
Unfortunately, an elevated D-Dimer level is not specific for VTE. There are many other situations that will yield increased levels, such as cancer, trauma, prganancy, inflammation, surgery, advancing age, and extended bed-rest. However, it is extremely unlikely that a paitent with an acute VTE will have D-Dimer levels in the normal range. Therefore, the clinical utility of the D-Dimer assay is its ability to assist in "ruling out" a diagnosis of VTE.
Alternative Name(s): N/A
Supply: 38445 Light Blue 4.5mL 3.2% SODIUM CITRATE
Preferred Specimen: One Full Unopened 3.2% Sodium Citrate (Light Blue-Top) Tube
Preferred Volume: 4.5mL
A completely filled tube is necessary because the correct ratio of blood to citrate is critical (9:1). Mix by gentle inversion 3-4 times. Do not uncap.
Instructions: a completely filled tube is necessary because the correct ratio of blood to citrate is critical (9:1). Mix by gentle inversion 3-4 times. Do not uncap. Minimum Volume Ratio of blood to citrate is critical.
Transport Container: 3.2% Sodium Citrate (Light Blue-Top) Tube
Transport Temperature: Room Temperature
Specimen Stability: Room Temperature: 72 Hours
- Improper Blood To Citrate Ratio
- Grossly hemolyzed specimens
- Improper Blood Collection
For additional supply or collection device information, please contact DLO's Customer Service at (800) 891-2917, option 2.
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