Alanine Aminotransferase (ALT)Main Content
Test Code: 823
Methodology: Spectrophotometry (SP)
Clinical Significance: Alanine Aminotransferase (ALT) measurements are particularly useful in the diagnosis and management of certain liver diseases, e.g., viral hepatitis and cirrhosis. ALT activity in tissue is generally much lower than aspartate aminotransferase (AST) activity and is found in highest concentrations in the liver. Significant elevations of ALT occur only in diseases of the liver. ALT is often measured in conjunction with AST to determine whether the source of the AST is the liver or the heart. ALT is normally not elevated in cases of myocardial infarction, i.e., a normal ALT, in conjunction with an elevated AST, tends to suggest cardiac disease. However, slight elevations of ALT may occur if an infarct destroys a very large volume of heart muscle.
Alternative Name(s): ALT, SGPT
Supply: T01 - Red/Gray SST 8.5mL
Preferred Specimen: Serum
Preferred Volume: 1mL
Transport Container: Serum Separator Tube (SST)
Transport Temperature: Room Temperature
Specimen Stability: Room Temperature: 4 days
Rejection Criteria: Specimens exceeding stability; Unlabeled or improperly labeled specimens; Specimens other than serum
NOTE: The assay manufacturer, Beckman Coulter, warns that patients treated with Sulfalazine may generate false low results for ALT. Trauma to striated muscle, tissue, rhabdomyolysis, polymyositis, and dermatomyositis may produce increased results. Hemolyzed samples may yield elevated results. Some illegal drugs (cocaine, anabolic steroids, ecstasy) may also produce increased results.
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