The American Medical Association (AMA) has made Current Procedural Terminology CPT® code changes to the 2025 edition of the CPT®. Diagnostic Laboratory of Oklahoma (DLO) will be implementing these changes effective January 1, 2025. Overall, the changes for 2025 CPT® coding affect the way we bill some of our tests. These tests may also be included in panels or profiles. The chart below lists some of the tests affected and the appropriate CPT code changes. Please refer to the Quest Diagnostics Test Directory for further detail on reflexing information.
Download a PDF of the CPT Code Changes for 2025 Table
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The American Medical Association (AMA) has made Current Procedural Terminology CPT® code changes to the 2025 edition of the CPT.
Diagnostic Laboratory of Oklahoma (DLO) will be implementing these changes effective January 1, 2025. Overall, the changes for 2025 AMA CPT coding affect the way we bill some of our tests. These tests may also be included in panels or profiles. The chart below lists some of the tests affected and the appropriate CPT code changes. Please refer to the Quest Diagnostics Test Directory for further detail on reflexing information.
Download a PDF of the CPT® Code Changes for 2024 Table
| Order Code | Test Name | 2024 CPT Coding | 2025 CPT Coding |
|---|---|---|---|
| 11786 | Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma | 0346U | 82233, 82234 |
| 13690 | Tau Protein, Phosphorylated | 83520 | 84393 |
| 92433 | ADmark® Phospho-Tau/Total-Tau/A Beta42, Analysis and Interpretation, CSF (Symptomatic) | 83520 (x3) | 84393, 82234, 84394 |
| 13825 | Quest AD-Detect® Phosphorylated tau217(p-tau217), Plasma | 83520 | 84393 |
| 94628 | Beta-Amyloid 42/40 Ratio and Apolipoprotein E (APOE) Isoform Panel, CSF | 82542 (x2), 82172 | 82233, 82234, 82172 |
| 94627 | Beta-Amyloid 42/40 Ratio, CSF | 82542 | 82233, 82234 |
| 37989 | 14-3-3 Protein, CSF (Prion Disease) | 0035U, 83520 (x2) | 0035U, 83520, 84394 |
| 18835 | Pneumocystis jirovecii DNA, Qualitative Real-time PCR | 87798 | 87594 |
| 94577 | Mycobacterium tuberculosis Complex and Rifampin Resistance, PCR, Sputum | 87801 | 87564 |
| 94578 | Mycobacterium tuberculosis Complex, Rifampin Resistance, Culture/PCR Sputum | 87801, 87116, 87206 | 87564, 87116, 87206 |
| 36925 | Mycobacterium tuberculosis Complex and Rifampin Resistance, PCR, Non-Sputum | 87801 | 87564 |
| 13240 | PFAS (Forever Chemicals) 9 Panel | 0457U effective 7/1/2024 | 0457U |
| 92587 | BRCA Panel Plus | 81162, 81307, 81321, 81323, 81351, 81404, 81405, 81406, 81479 |
81432 |
| 91461 | Lynch Syndrome Panel | 81295, 81297, 81292, 81294, 81298, 81300, 81317, 81319, 81403 | 81435 |
| 38611 | Guideline Based Hereditary Cancer Panel | Breast: 81432, 81433 - or - Colon: 81435, 81436 | Breast: 81432 - or - Colon: 81435 |
| 38621 | Hereditary Breast Cancer Panel | 81432, 81433 | 81432 |
| 38600 | Comprehensive Hereditary Cancer Panel | Breast: 81432, 81433 - or - Colon: 81435, 81436 | Breast: 81432 - or - Colon: 81435 |
| 38641 | Hereditary Endocrine Cancer Panel | 81437, 81438 | 81437 |
| 38631 | Hereditary Colorectal Cancer Panel | 81435, 81436 | 81435 |
| 13979 | Neurofilament Light Chain (NfL), Plasma | 83520 | 83884 |
| 16374 | S. pneumoniae Antibody (IgG), 13 Serotypes | 86317 (x13) | 86581 |
| 19564 | S. pneumoniae Antibody (IgG), 14 Serotypes | 86317 (x14) | 86581 |
| 16963 | S. pneumoniae Antibody (IgG), 23 Serotypes | 86317 (x23) | 86581 |
| 19817 | S. pneumoniae Antibody (IgG), 12 Serotypes | 86317 (x12) | 86581 |
We appreciate your support and look forward to continuing to serve all of your laboratory needs. DLO will make every effort to assist you with the transition to the 2025 AMA CPT coding being used for our test offerings.
Thank you very much for using DLO for your laboratory testing needs.
Note: The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
