ICD-10 AND CPT 2021

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The American Medical Association (AMA) has made Current Procedural Terminology CPT® code changes to the 2021 edition of the CPT.

Diagnostic Laboratory of Oklahoma (DLO) will be implementing these changes effective January 1, 2021. Overall, the changes for 2021 AMA CPT coding affect the way we bill some of our tests. These tests may also be included in panels or profiles. The chart below lists some of the tests affected and the appropriate CPT code changes.

DLO Order Code DLO Test Name 2020 CPT Coding 2021 CPT Coding
92476 MPL Mutation Analysis 81403 81339
92472 JAK2 V617F Cascading Reflex to CALR, JAK2 Exon 12, MPL, and CSF3R 81270 with reflex to CALR (calreticulin) (CPT code: 81219), then exon 12 of JAK2 (CPT code: 81403), then codon 505 and 515 of MPL (CPT code: 81403), and then two mutational hotspots in the CSF3R gene (CPT code: 81479) 81270 with reflex to CALR (calreticulin) (CPT code: 81219), then exon 12 of JAK2 (CPT code: 81279), then codon 505 and 515 of MPL (CPT code: 81339), and then two mutational hotspots in the CSF3R gene (CPT code: 81479)
92474 JAK2 Exon 12 Mutation Analysis 81403 81279
14991 Mantle Cell Lymphona, BCL- 1/JH T(11.14) Cell Based 81401 81168
15007 Follicular Lymphoma bcl-2JH t(14 18) Real-time PCR Cell- based 81402 81278
16515 TP53 Somatic Mutation, Prognostic 81405 81351
92560 Li-Fraumeni Syndrome, TP53 Sequencing and Deletion/Duplication 81405, 81479 81351, 81479
92587 BRCAvantage® (BRCA1, BRCA2, TP53, PTEN, CDH1, STK11, PALB2) 81162, 81307, 81321, 81323, 81404, 81405 (x2), 81406, 81479 81162, 81307, 81321, 81323, 81351, 81404, 81405, 81406, 81479
201 Acetaminophen 80299 80143
36721 Amiodarone 80299 80151
36676 Carbamazepine- 10, 11 Epoxide, Serum/Plasma 80156 80161
26513 Carbamazepine and Metabolite, Total 80156 80156, 80161
7933 Carbamazepine and Metabolite, Free/Bound 80156, 80157 80156, 80157, 80161
3081 Felbamate 80299 80167
5309 Flecainide 80299 80181
94092 Itraconazole 80299 80189
18865 Leflunomide 80299 80193
648 Methotrexate 80299 80204
16296 Rufinamide 80299 80210
805 Salicylate 80299 80179
36169 Estradiol, Free 82670 (x2) 82670, 82681

We appreciate your support and look forward to continuing to serve all of your laboratory needs. DLO will make every effort to assist you with the transition to the 2021 AMA CPT coding being used for our test offerings.

Thank you very much for using DLO for your laboratory testing needs.

Note: The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.