BMP - Basic Metabolic Panel

Test Code: 10165

CPT Code(s): 80048

Includes: BUN/Creatinine Ratio (calculated), Calcium, Carbon Dioxide, Chloride, Creatinine with GFR Estimated, Glucose, Potassium, Sodium, Urea Nitrogen (BUN)

Patient Preparation: Fasting specimen is preferred

Alternative Name(s): BMP, Metabolic Panels

Basic Metabolic Panel without eGFR
Test Code: 19108
CPT Code(s): 80048
Includes: Glucose, Urea Nitrogen (BUN), Creatinine, BUN/Creatinine Ratio, Sodium, Potassium, Chloride, Carbon Dioxide, Calcium, Lipemia, Icterus, Hemolysis

Methodology: See individual test

Clinical Significance: Basic Metabolic Panel - This panel comprises a group of 8 specific tests that provide information on the status of an individual’s blood electrolytes, glucose levels, kidney status, and acid-base balance. The panel is usually ordered as part of a routine health examination or physical [1].

The Basic Metabolic Panel is also commonly ordered during hospital and emergency-room admission, and to monitor the metabolism and vital signs of hospitalized individuals with conditions, such as hypertension, who are being treated with diuretics or other appropriate interventions. [1].

Significant changes in electrolytes, acid-base balance, renal function, and blood glucose may be associated with kidney failure, respiratory distress, and impaired cognitive status. Changes in sodium, potassium, and calcium alter the excitability of neurons, cardiac, and skeletal muscles that can produce arrhythmias, weakness, and spasms/tremors [1].

Basic metabolic panel test results are usually evaluated in conjunction with one another for patterns of results. A single abnormal test result could be indicative of something different than if more than 1 of the test results are abnormal. Many conditions can cause abnormal results, including kidney failure, respiratory distress, and diabetes-related complications [1].

The section below outlines the roles of the analytes assessed with this panel [1].

1. Sodium: Plays a central role in maintaining the normal distribution of water and osmotic pressure.
2. Potassium: Essential for proper muscle and nerve function.
3. Chloride: Helps keep the balance of fluids, maintain blood volume, stabilize blood pressure, and balance the pH of body fluids.
4. CO2 (carbon dioxide, bicarbonate): Used to evaluate the total carbonate buffering system and acid-base balance.
5. Glucose: A critical energy source for cells and organs. Used to diagnose diabetes and hypoglycemia.
6. Calcium: Essential for nerve, muscle, and heart functions and bone formation.
7. BUN (blood urea nitrogen): Evaluation of kidney function.
8. Creatinine: Useful for diagnosis of renal insufficiency and estimation of glomerular filtration rate.

References
1. Rao LV, et al. Laboratory tests. In Rao LV, eds. Wallach's Interpretation of Diagnostic Tests. Pathways to Arriving at a Clinical Diagnosis. 11th ed. New York, NY: Wolters Kluwer; 2020, 6-463.