Test Code: 4021
Methodology: Immunoassay (IA)
Clinical Significance: Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.
Alternative Name(s): 17-Beta-Estradiol; E2; E2 IVR; Estradiol (E2-6 III); Estradiol Level; Estradiol 17 Beta; IVR Estradiol
Supply: T01 - Red/Gray SST 8.5mL
Preferred Specimen: Serum
Preferred Volume: 1mL
Transport Container: Serum Separator Tube (SST)
Transport Temperature: Room Temperature
Specimen Stability: Room Temperature: 7 days
SPECIAL INSTRUCTIONS: For any patients for whom low estradiol levels are anticipated (e.g. males, pre-pubertal children, and hypogonadal/post-menopausal femails), the Quest Diagnostic Nichols Institue Estradiol, Ultrasensitive LC/MS/MS Assay is recommended (order code 30289).
Note: DO NOT add on estradiol testing to a barrier gel specimen older than 72 hours. Estradiol binds to barrier gel causing decreased values.
Rejection Criteria: Serum stored on barrier gel for more than 72 hours
For additional supply or collection device information, please contact DLO's Customer Service at (800) 891-2917, option 2.