Clone of BRCAvantage with Reflex to Breast Plus Panel
Breast Plus Panel without BRCA (TP53, STK11, PTEN, CDH1, PALB2)
Test Code: 92586
CPT Code(s): 81321, 81323, 81404, 81405 (x2), 81406 (x2), 81479
Clinical Significance: CDH1, PALB2, PTEN, STK11 and TP53 are tumor suppressor genes, where inherited mutations significantly increase breast cancer risk. Sequence analysis and deletion/duplication analysis of these five genes can explain an additional 3% to 4.5% of hereditary breast cancers.